Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Identifieur interne : 006097 ( Main/Exploration ); précédent : 006096; suivant : 006098Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Auteurs : Carl A. Anderson [Royaume-Uni] ; Gabrielle Boucher [Canada] ; Charlie W. Lees [Royaume-Uni] ; Andre Franke [Allemagne] ; Mauro D Mato [Suède] ; Kent D. Taylor [États-Unis] ; James C. Lee [Royaume-Uni] ; Philippe Goyette [Canada] ; Marcin Imielinski [États-Unis] ; Anna Latiano [Italie] ; Caroline Lagacé [Canada] ; Regan Scott [États-Unis] ; Leila Amininejad [Belgique] ; Suzannah Bumpstead [Royaume-Uni] ; Leonard Baidoo [États-Unis] ; Robert N. Baldassano [États-Unis] ; Murray Barclay [Nouvelle-Zélande] ; Theodore M. Bayless [États-Unis] ; Stephan Brand [Allemagne] ; Carsten Büning [Allemagne] ; Jean-Frédéric Colombel [France] ; Lee A. Denson [États-Unis] ; Martine De Vos [Belgique] ; Marla Dubinsky [États-Unis] ; Cathryn Edwards [Royaume-Uni] ; David Ellinghaus [Allemagne] ; Rudolf S. N. Fehrmann [Pays-Bas] ; James A. B. Floyd [Royaume-Uni] ; Tim Florin [Australie] ; Denis Franchimont [Belgique] ; Lude Franke [Pays-Bas] ; Michel Georges [Belgique] ; Jürgen Glas [Allemagne] ; Nicole L. Glazer [États-Unis] ; Stephen L. Guthery [États-Unis] ; Talin Haritunians [États-Unis] ; Nicholas K. Hayward [Australie] ; Jean-Pierre Hugot [France] ; Gilles Jobin [Canada] ; Debby Laukens [Belgique] ; Ian Lawrance [Australie] ; Marc Lémann [France] ; Arie Levine [Israël] ; Cecile Libioulle [Belgique] ; Edouard Louis [Belgique] ; Dermot P. Mcgovern [États-Unis] ; Monica Milla [Italie] ; Grant W. Montgomery [Australie] ; Katherine I. Morley [Royaume-Uni] ; Craig Mowat [Royaume-Uni] ; Aylwin Ng [États-Unis] ; William Newman [Royaume-Uni] ; Roel A. Ophoff [Pays-Bas] ; Laura Papi [Italie] ; Orazio Palmieri [Italie] ; Laurent Peyrin-Biroulet [France] ; Julián Panés [Espagne] ; Anne Phillips [Royaume-Uni] ; Natalie J. Prescott [Royaume-Uni] ; Deborah D. Proctor [États-Unis] ; Rebecca Roberts [Nouvelle-Zélande] ; Richard Russell [Royaume-Uni] ; Paul Rutgeerts [Belgique] ; Jeremy Sanderson [Royaume-Uni] ; Miquel Sans [Espagne] ; Philip Schumm [États-Unis] ; Frank Seibold [Suisse] ; Yashoda Sharma [États-Unis] ; Lisa Simms [Australie] ; Mark Seielstad [Singapour, États-Unis] ; A. Hillary Steinhart [Canada] ; Stephan R. Targan [États-Unis] ; Leonard H. Van Den Berg [Pays-Bas] ; Morten Vatn [Norvège] ; Hein Verspaget [Pays-Bas] ; Thomas Walters [Canada] ; Cisca Wijmenga [Pays-Bas] ; David C. Wilson [Royaume-Uni] ; Harm-Jan Westra [Pays-Bas] ; Ramnik J. Xavier [États-Unis] ; Zhen Z. Zhao [Australie] ; Cyriel Y. Ponsioen [Pays-Bas] ; Vibeke Andersen [Danemark] ; Leif Torkvist [Suède] ; Maria Gazouli [Grèce] ; Nicholas P. Anagnou [Grèce] ; Tom H. Karlsen [Norvège] ; Limas Kupcinskas [Lituanie] ; Jurgita Sventoraityte [Lituanie] ; John C. Mansfield [Royaume-Uni] ; Subra Kugathasan [États-Unis] ; Mark S. Silverberg [Canada] ; Jonas Halfvarson [Suède] ; Jerome I. Rotter [États-Unis] ; Christopher G. Mathew [Royaume-Uni] ; Anne M. Griffiths [Canada] ; Richard Gearry [Nouvelle-Zélande] ; Tariq Ahmad [Royaume-Uni] ; Steven R. Brant [États-Unis] ; Mathias Chamaillard [France] ; Jack Satsangi [Royaume-Uni] ; Judy H. Cho [États-Unis] ; Stefan Schreiber [Allemagne] ; Mark J. Daly [États-Unis] ; Jeffrey C. Barrett [Royaume-Uni] ; Miles Parkes [Royaume-Uni] ; Vito Annese [Italie] ; Hakon Hakonarson [États-Unis] ; Graham Radford-Smith [Australie] ; Richard H. Duerr [États-Unis] ; Séverine Vermeire [Belgique] ; Rinse K. Weersma [Pays-Bas] ; John D. Rioux [Canada]Source :
- Nature genetics [ 1061-4036 ] ; 2011.
Abstract
Genome-wide association studies (GWAS) and candidate gene studies in ulcerative colitis (UC) have identified 18 susceptibility loci. We conducted a meta-analysis of 6 UC GWAS, comprising 6,687 cases and 19,718 controls, and followed-up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P<5×10-8), increasing the number of UC associated loci to 47. After annotating associated regions using GRAIL, eQTL data and correlations with non-synonymous SNPs, we identified many candidate genes providing potentially important insights into disease pathogenesis, including
Url:
DOI: 10.1038/ng.764
PubMed: 21297633
PubMed Central: 3084597
Affiliations:
- Allemagne, Australie, Belgique, Canada, Danemark, Espagne, France, Grèce, Israël, Italie, Lituanie, Norvège, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Singapour, Suisse, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Attique (région), Bavière, Berlin, Californie, Canton de Berne, Catalogne, Connecticut, District de Haute-Bavière, Grand Est, Grand Londres, Grand Manchester, Groningue (province), Géorgie (États-Unis), Hauts-de-France, Hollande-Méridionale, Hollande-Septentrionale, Illinois, Lorraine (région), Maryland, Massachusetts, Nord-Pas-de-Calais, Ohio, Ontario, Pennsylvanie, Province de Liège, Région de Bruxelles-Capitale, Région wallonne, Schleswig-Holstein, Svealand, Utah, Utrecht (province), Washington (État), Écosse, Île-de-France, Østlandet
- Amsterdam, Athènes, Barcelone, Berlin, Berne, Bruxelles, Cambridge, Groningue, Kiel, Leyde, Lille, Liège, Londres, Manchester, Munich, Nancy, Oslo, Paris, Seattle, Stockholm, Toronto, Utrecht, Vandœuvre-lès-Nancy, Édimbourg
- Université d'Édimbourg, Université de Berne, Université de Cambridge, Université de Liège, Université de Toronto, Université de Washington
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Le document en format XML
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Bayless</name><affiliation wicri:level="2"><nlm:aff id="A15">Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brand, Stephan" sort="Brand, Stephan" uniqKey="Brand S" first="Stephan" last="Brand">Stephan Brand</name><affiliation wicri:level="3"><nlm:aff id="A16">University Hospital Munich, Department of Medicine II, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Munich, Department of Medicine II, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Buning, Carsten" sort="Buning, Carsten" uniqKey="Buning C" first="Carsten" last="Büning">Carsten Büning</name><affiliation wicri:level="3"><nlm:aff id="A17">Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Colombel, Jean Frederic" sort="Colombel, Jean Frederic" uniqKey="Colombel J" first="Jean-Frédéric" last="Colombel">Jean-Frédéric Colombel</name><affiliation wicri:level="3"><nlm:aff id="A18">Université de Lille Department of Hepato-Gastroenterology, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Lille Department of Hepato-Gastroenterology, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Denson, Lee A" sort="Denson, Lee A" uniqKey="Denson L" first="Lee A." last="Denson">Lee A. Denson</name><affiliation wicri:level="2"><nlm:aff id="A19">Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="De Vos, Martine" sort="De Vos, Martine" uniqKey="De Vos M" first="Martine" last="De Vos">Martine De Vos</name><affiliation wicri:level="1"><nlm:aff id="A20">Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Dubinsky, Marla" sort="Dubinsky, Marla" uniqKey="Dubinsky M" first="Marla" last="Dubinsky">Marla Dubinsky</name><affiliation wicri:level="2"><nlm:aff id="A21">Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Edwards, Cathryn" sort="Edwards, Cathryn" uniqKey="Edwards C" first="Cathryn" last="Edwards">Cathryn Edwards</name><affiliation wicri:level="1"><nlm:aff id="A22">Torbay Hospital, Department of Gastroenterology, Torbay, Devon, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Torbay Hospital, Department of Gastroenterology, Torbay, Devon</wicri:regionArea><wicri:noRegion>Devon</wicri:noRegion></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Fehrmann, Rudolf S N" sort="Fehrmann, Rudolf S N" uniqKey="Fehrmann R" first="Rudolf S. N." last="Fehrmann">Rudolf S. N. Fehrmann</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Floyd, James A B" sort="Floyd, James A B" uniqKey="Floyd J" first="James A. B." last="Floyd">James A. B. Floyd</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Florin, Tim" sort="Florin, Tim" uniqKey="Florin T" first="Tim" last="Florin">Tim Florin</name><affiliation wicri:level="1"><nlm:aff id="A24">Mater Health Services, Department of Gastroenterology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Mater Health Services, Department of Gastroenterology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Franchimont, Denis" sort="Franchimont, Denis" uniqKey="Franchimont D" first="Denis" last="Franchimont">Denis Franchimont</name><affiliation wicri:level="3"><nlm:aff id="A25">Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Georges, Michel" sort="Georges, Michel" uniqKey="Georges M" first="Michel" last="Georges">Michel Georges</name><affiliation wicri:level="4"><nlm:aff id="A26">University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Glas, Jurgen" sort="Glas, Jurgen" uniqKey="Glas J" first="Jürgen" last="Glas">Jürgen Glas</name><affiliation wicri:level="3"><nlm:aff id="A16">University Hospital Munich, Department of Medicine II, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Munich, Department of Medicine II, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation wicri:level="4"><nlm:aff id="A27">University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Guthery, Stephen L" sort="Guthery, Stephen L" uniqKey="Guthery S" first="Stephen L." last="Guthery">Stephen L. Guthery</name><affiliation wicri:level="2"><nlm:aff id="A28">University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Hugot, Jean Pierre" sort="Hugot, Jean Pierre" uniqKey="Hugot J" first="Jean-Pierre" last="Hugot">Jean-Pierre Hugot</name><affiliation wicri:level="3"><nlm:aff id="A31">Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jobin, Gilles" sort="Jobin, Gilles" uniqKey="Jobin G" first="Gilles" last="Jobin">Gilles Jobin</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A32">Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Laukens, Debby" sort="Laukens, Debby" uniqKey="Laukens D" first="Debby" last="Laukens">Debby Laukens</name><affiliation wicri:level="1"><nlm:aff id="A20">Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Lawrance, Ian" sort="Lawrance, Ian" uniqKey="Lawrance I" first="Ian" last="Lawrance">Ian Lawrance</name><affiliation wicri:level="1"><nlm:aff id="A33">The University of Western Australia, School of Medicine and Pharmacology, Fremantle, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Western Australia, School of Medicine and Pharmacology, Fremantle</wicri:regionArea><wicri:noRegion>Fremantle</wicri:noRegion></affiliation></author><author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lémann">Marc Lémann</name><affiliation wicri:level="3"><nlm:aff id="A34">Université Paris Diderot, GETAID group, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, GETAID group, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Levine, Arie" sort="Levine, Arie" uniqKey="Levine A" first="Arie" last="Levine">Arie Levine</name><affiliation wicri:level="1"><nlm:aff id="A35">Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Libioulle, Cecile" sort="Libioulle, Cecile" uniqKey="Libioulle C" first="Cecile" last="Libioulle">Cecile Libioulle</name><affiliation wicri:level="1"><nlm:aff id="A36">Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Louis, Edouard" sort="Louis, Edouard" uniqKey="Louis E" first="Edouard" last="Louis">Edouard Louis</name><affiliation wicri:level="1"><nlm:aff id="A36">Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Mcgovern, Dermot P" sort="Mcgovern, Dermot P" uniqKey="Mcgovern D" first="Dermot P." last="Mcgovern">Dermot P. Mcgovern</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Milla, Monica" sort="Milla, Monica" uniqKey="Milla M" first="Monica" last="Milla">Monica Milla</name><affiliation wicri:level="1"><nlm:aff id="A37">AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>AOU Careggi, Unit of Gastroenterology SOD2, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Morley, Katherine I" sort="Morley, Katherine I" uniqKey="Morley K" first="Katherine I." last="Morley">Katherine I. Morley</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mowat, Craig" sort="Mowat, Craig" uniqKey="Mowat C" first="Craig" last="Mowat">Craig Mowat</name><affiliation wicri:level="1"><nlm:aff id="A38">Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ninewells Hospital and Medical School, Dept of Medicine, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Aylwin" sort="Ng, Aylwin" uniqKey="Ng A" first="Aylwin" last="Ng">Aylwin Ng</name><affiliation wicri:level="2"><nlm:aff id="A39">Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A40">Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Newman, William" sort="Newman, William" uniqKey="Newman W" first="William" last="Newman">William Newman</name><affiliation wicri:level="3"><nlm:aff id="A41">University of Manchester Department of Medical Genetics, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester Department of Medical Genetics, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A" last="Ophoff">Roel A. Ophoff</name><affiliation wicri:level="3"><nlm:aff id="A42">University Medical Center Utrecht, Department of Medical Genetics, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Department of Medical Genetics, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation wicri:level="1"><nlm:aff id="A43">University of Florence, Institute of Human Genetics, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Florence, Institute of Human Genetics, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Palmieri, Orazio" sort="Palmieri, Orazio" uniqKey="Palmieri O" first="Orazio" last="Palmieri">Orazio Palmieri</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Peyrin Biroulet, Laurent" sort="Peyrin Biroulet, Laurent" uniqKey="Peyrin Biroulet L" first="Laurent" last="Peyrin-Biroulet">Laurent Peyrin-Biroulet</name><affiliation wicri:level="3"><nlm:aff id="A44">University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Panes, Julian" sort="Panes, Julian" uniqKey="Panes J" first="Julián" last="Panés">Julián Panés</name><affiliation wicri:level="3"><nlm:aff id="A45">Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Phillips, Anne" sort="Phillips, Anne" uniqKey="Phillips A" first="Anne" last="Phillips">Anne Phillips</name><affiliation wicri:level="1"><nlm:aff id="A38">Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ninewells Hospital and Medical School, Dept of Medicine, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Prescott, Natalie J" sort="Prescott, Natalie J" uniqKey="Prescott N" first="Natalie J." last="Prescott">Natalie J. Prescott</name><affiliation wicri:level="3"><nlm:aff id="A46">King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Proctor, Deborah D" sort="Proctor, Deborah D" uniqKey="Proctor D" first="Deborah D." last="Proctor">Deborah D. Proctor</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Roberts, Rebecca" sort="Roberts, Rebecca" uniqKey="Roberts R" first="Rebecca" last="Roberts">Rebecca Roberts</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Richard" sort="Russell, Richard" uniqKey="Russell R" first="Richard" last="Russell">Richard Russell</name><affiliation wicri:level="1"><nlm:aff id="A48">Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Rutgeerts, Paul" sort="Rutgeerts, Paul" uniqKey="Rutgeerts P" first="Paul" last="Rutgeerts">Paul Rutgeerts</name><affiliation wicri:level="1"><nlm:aff id="A49">University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sanderson, Jeremy" sort="Sanderson, Jeremy" uniqKey="Sanderson J" first="Jeremy" last="Sanderson">Jeremy Sanderson</name><affiliation wicri:level="3"><nlm:aff id="A50">Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sans, Miquel" sort="Sans, Miquel" uniqKey="Sans M" first="Miquel" last="Sans">Miquel Sans</name><affiliation wicri:level="3"><nlm:aff id="A51">Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Schumm, Philip" sort="Schumm, Philip" uniqKey="Schumm P" first="Philip" last="Schumm">Philip Schumm</name><affiliation wicri:level="2"><nlm:aff id="A52">University of Chicago, Department of Health Studies, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Department of Health Studies, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Seibold, Frank" sort="Seibold, Frank" uniqKey="Seibold F" first="Frank" last="Seibold">Frank Seibold</name><affiliation wicri:level="4"><nlm:aff id="A53">University of Bern, Division of Gastroenterology, Inselspital, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Bern, Division of Gastroenterology, Inselspital, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Sharma, Yashoda" sort="Sharma, Yashoda" uniqKey="Sharma Y" first="Yashoda" last="Sharma">Yashoda Sharma</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Simms, Lisa" sort="Simms, Lisa" uniqKey="Simms L" first="Lisa" last="Simms">Lisa Simms</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Seielstad, Mark" sort="Seielstad, Mark" uniqKey="Seielstad M" first="Mark" last="Seielstad">Mark Seielstad</name><affiliation wicri:level="1"><nlm:aff id="A54">Genome Institute of Singapore, Human Genetics, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore, Human Genetics</wicri:regionArea><wicri:noRegion>Human Genetics</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A55">Institute for Human Genetics, University of California San Fransisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Human Genetics, University of California San Fransisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Steinhart, A Hillary" sort="Steinhart, A Hillary" uniqKey="Steinhart A" first="A. Hillary" last="Steinhart">A. Hillary Steinhart</name><affiliation wicri:level="4"><nlm:aff id="A56">University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Targan, Stephan R" sort="Targan, Stephan R" uniqKey="Targan S" first="Stephan R." last="Targan">Stephan R. Targan</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="3"><nlm:aff id="A57">Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Vatn, Morten" sort="Vatn, Morten" uniqKey="Vatn M" first="Morten" last="Vatn">Morten Vatn</name><affiliation wicri:level="3"><nlm:aff id="A58">Rikshospitalet University Hospital, Medical Department, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Rikshospitalet University Hospital, Medical Department, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Verspaget, Hein" sort="Verspaget, Hein" uniqKey="Verspaget H" first="Hein" last="Verspaget">Hein Verspaget</name><affiliation wicri:level="3"><nlm:aff id="A59">Leiden University Medical Center, Experimental Gastroenterology, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Experimental Gastroenterology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Walters, Thomas" sort="Walters, Thomas" uniqKey="Walters T" first="Thomas" last="Walters">Thomas Walters</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Wilson, David C" sort="Wilson, David C" uniqKey="Wilson D" first="David C." last="Wilson">David C. Wilson</name><affiliation wicri:level="1"><nlm:aff id="A48">Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A61">Child Life and Health, University of Edinburgh, Scotland</nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Child Life and Health, University of Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Xavier, Ramnik J" sort="Xavier, Ramnik J" uniqKey="Xavier R" first="Ramnik J." last="Xavier">Ramnik J. Xavier</name><affiliation wicri:level="2"><nlm:aff id="A39">Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A40">Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhao, Zhen Z" sort="Zhao, Zhen Z" uniqKey="Zhao Z" first="Zhen Z." last="Zhao">Zhen Z. Zhao</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Ponsioen, Cyriel Y" sort="Ponsioen, Cyriel Y" uniqKey="Ponsioen C" first="Cyriel Y." last="Ponsioen">Cyriel Y. Ponsioen</name><affiliation wicri:level="3"><nlm:aff id="A62">Academic Medical Center, Department of Gastroenterology, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Academic Medical Center, Department of Gastroenterology, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Andersen, Vibeke" sort="Andersen, Vibeke" uniqKey="Andersen V" first="Vibeke" last="Andersen">Vibeke Andersen</name><affiliation wicri:level="1"><nlm:aff id="A63">Viborg Regional Hospital, Medical Department, Viborg, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Viborg Regional Hospital, Medical Department, Viborg</wicri:regionArea><wicri:noRegion>Viborg</wicri:noRegion></affiliation></author><author><name sortKey="Torkvist, Leif" sort="Torkvist, Leif" uniqKey="Torkvist L" first="Leif" last="Torkvist">Leif Torkvist</name><affiliation wicri:level="3"><nlm:aff id="A64">Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gazouli, Maria" sort="Gazouli, Maria" uniqKey="Gazouli M" first="Maria" last="Gazouli">Maria Gazouli</name><affiliation wicri:level="3"><nlm:aff id="A65">University of Athens, Department of Biology, School of Medicine, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Athens, Department of Biology, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Anagnou, Nicholas P" sort="Anagnou, Nicholas P" uniqKey="Anagnou N" first="Nicholas P." last="Anagnou">Nicholas P. Anagnou</name><affiliation wicri:level="3"><nlm:aff id="A65">University of Athens, Department of Biology, School of Medicine, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Athens, Department of Biology, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H." last="Karlsen">Tom H. Karlsen</name><affiliation wicri:level="3"><nlm:aff id="A58">Rikshospitalet University Hospital, Medical Department, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Rikshospitalet University Hospital, Medical Department, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Kupcinskas, Limas" sort="Kupcinskas, Limas" uniqKey="Kupcinskas L" first="Limas" last="Kupcinskas">Limas Kupcinskas</name><affiliation wicri:level="1"><nlm:aff id="A66">Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Kaunas University of medicine, Department of Gastroenterology, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Sventoraityte, Jurgita" sort="Sventoraityte, Jurgita" uniqKey="Sventoraityte J" first="Jurgita" last="Sventoraityte">Jurgita Sventoraityte</name><affiliation wicri:level="1"><nlm:aff id="A66">Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Kaunas University of medicine, Department of Gastroenterology, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Mansfield, John C" sort="Mansfield, John C" uniqKey="Mansfield J" first="John C." last="Mansfield">John C. Mansfield</name><affiliation wicri:level="1"><nlm:aff id="A67">Newcastle University, Institute of Human Genetics, Newcastle upon Tyne, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Newcastle University, Institute of Human Genetics, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Kugathasan, Subra" sort="Kugathasan, Subra" uniqKey="Kugathasan S" first="Subra" last="Kugathasan">Subra Kugathasan</name><affiliation wicri:level="2"><nlm:aff id="A68">Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Silverberg, Mark S" sort="Silverberg, Mark S" uniqKey="Silverberg M" first="Mark S." last="Silverberg">Mark S. Silverberg</name><affiliation wicri:level="4"><nlm:aff id="A56">University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Halfvarson, Jonas" sort="Halfvarson, Jonas" uniqKey="Halfvarson J" first="Jonas" last="Halfvarson">Jonas Halfvarson</name><affiliation wicri:level="1"><nlm:aff id="A69">Örebro University Hospital, Department of Medicine, Örebro, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Örebro University Hospital, Department of Medicine, Örebro</wicri:regionArea><wicri:noRegion>Örebro</wicri:noRegion></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mathew, Christopher G" sort="Mathew, Christopher G" uniqKey="Mathew C" first="Christopher G." last="Mathew">Christopher G. Mathew</name><affiliation wicri:level="3"><nlm:aff id="A46">King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Griffiths, Anne M" sort="Griffiths, Anne M" uniqKey="Griffiths A" first="Anne M." last="Griffiths">Anne M. Griffiths</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gearry, Richard" sort="Gearry, Richard" uniqKey="Gearry R" first="Richard" last="Gearry">Richard Gearry</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Tariq" sort="Ahmad, Tariq" uniqKey="Ahmad T" first="Tariq" last="Ahmad">Tariq Ahmad</name><affiliation wicri:level="1"><nlm:aff id="A70">Peninsula College of Medicine and Dentistry, Barrack Road, Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula College of Medicine and Dentistry, Barrack Road, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Brant, Steven R" sort="Brant, Steven R" uniqKey="Brant S" first="Steven R." last="Brant">Steven R. Brant</name><affiliation wicri:level="2"><nlm:aff id="A15">Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chamaillard, Mathias" sort="Chamaillard, Mathias" uniqKey="Chamaillard M" first="Mathias" last="Chamaillard">Mathias Chamaillard</name><affiliation wicri:level="3"><nlm:aff id="A71">Inserm, U1019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1019, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Satsangi, Jack" sort="Satsangi, Jack" uniqKey="Satsangi J" first="Jack" last="Satsangi">Jack Satsangi</name><affiliation wicri:level="4"><nlm:aff id="A4">University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Cho, Judy H" sort="Cho, Judy H" uniqKey="Cho J" first="Judy H." last="Cho">Judy H. Cho</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation><nlm:aff id="A72">Yale University, Department of Genetics, Yale School of Medicine, New Haven CT</nlm:aff><wicri:noCountry code="subfield">New Haven CT</wicri:noCountry></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A73">Department for General Internal Medicine, Christian-Albrechts-University, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for General Internal Medicine, Christian-Albrechts-University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J." last="Daly">Mark J. Daly</name><affiliation wicri:level="2"><nlm:aff id="A74">Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Barrett, Jeffrey C" sort="Barrett, Jeffrey C" uniqKey="Barrett J" first="Jeffrey C." last="Barrett">Jeffrey C. Barrett</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Parkes, Miles" sort="Parkes, Miles" uniqKey="Parkes M" first="Miles" last="Parkes">Miles Parkes</name><affiliation wicri:level="4"><nlm:aff id="A8">Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Annese, Vito" sort="Annese, Vito" uniqKey="Annese V" first="Vito" last="Annese">Vito Annese</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>AOU Careggi, Unit of Gastroenterology SOD2, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:aff id="A13">The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A75">Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Radford Smith, Graham" sort="Radford Smith, Graham" uniqKey="Radford Smith G" first="Graham" last="Radford-Smith">Graham Radford-Smith</name><affiliation wicri:level="1"><nlm:aff id="A76">Queensland Institute of Medical Research, IBD Research Group, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, IBD Research Group, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A77">University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Vermeire, Severine" sort="Vermeire, Severine" uniqKey="Vermeire S" first="Séverine" last="Vermeire">Séverine Vermeire</name><affiliation wicri:level="1"><nlm:aff id="A49">University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Weersma, Rinse K" sort="Weersma, Rinse K" uniqKey="Weersma R" first="Rinse K." last="Weersma">Rinse K. Weersma</name><affiliation wicri:level="3"><nlm:aff id="A78">University Medical Center Groningen, Department of Gastroenterology, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Gastroenterology, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D." last="Rioux">John D. Rioux</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21297633</idno><idno type="pmc">3084597</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597</idno><idno type="RBID">PMC:3084597</idno><idno type="doi">10.1038/ng.764</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002E05</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E05</idno><idno type="wicri:Area/Pmc/Curation">002C55</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C55</idno><idno type="wicri:Area/Pmc/Checkpoint">002244</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002244</idno><idno type="wicri:Area/Ncbi/Merge">000980</idno><idno type="wicri:Area/Ncbi/Curation">000980</idno><idno type="wicri:Area/Ncbi/Checkpoint">000980</idno><idno type="wicri:doubleKey">1061-4036:2011:Anderson C:meta:analysis:identifies</idno><idno type="wicri:Area/Main/Merge">006442</idno><idno type="wicri:Area/Main/Curation">006097</idno><idno type="wicri:Area/Main/Exploration">006097</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47</title><author><name sortKey="Anderson, Carl A" sort="Anderson, Carl A" uniqKey="Anderson C" first="Carl A." last="Anderson">Carl A. Anderson</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Charlie W" sort="Lees, Charlie W" uniqKey="Lees C" first="Charlie W." last="Lees">Charlie W. Lees</name><affiliation wicri:level="4"><nlm:aff id="A4">University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="D Mato, Mauro" sort="D Mato, Mauro" uniqKey="D Mato M" first="Mauro" last="D Mato">Mauro D Mato</name><affiliation wicri:level="3"><nlm:aff id="A6">Karolinska Institute, Department of Biosciences and Nutrition, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institute, Department of Biosciences and Nutrition, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. Taylor</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lee, James C" sort="Lee, James C" uniqKey="Lee J" first="James C." last="Lee">James C. Lee</name><affiliation wicri:level="4"><nlm:aff id="A8">Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Imielinski, Marcin" sort="Imielinski, Marcin" uniqKey="Imielinski M" first="Marcin" last="Imielinski">Marcin Imielinski</name><affiliation wicri:level="2"><nlm:aff id="A9">The Children’s Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Latiano, Anna" sort="Latiano, Anna" uniqKey="Latiano A" first="Anna" last="Latiano">Anna Latiano</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Lagace, Caroline" sort="Lagace, Caroline" uniqKey="Lagace C" first="Caroline" last="Lagacé">Caroline Lagacé</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Regan" sort="Scott, Regan" uniqKey="Scott R" first="Regan" last="Scott">Regan Scott</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Amininejad, Leila" sort="Amininejad, Leila" uniqKey="Amininejad L" first="Leila" last="Amininejad">Leila Amininejad</name><affiliation wicri:level="3"><nlm:aff id="A12">Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Bumpstead, Suzannah" sort="Bumpstead, Suzannah" uniqKey="Bumpstead S" first="Suzannah" last="Bumpstead">Suzannah Bumpstead</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Baidoo, Leonard" sort="Baidoo, Leonard" uniqKey="Baidoo L" first="Leonard" last="Baidoo">Leonard Baidoo</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Baldassano, Robert N" sort="Baldassano, Robert N" uniqKey="Baldassano R" first="Robert N." last="Baldassano">Robert N. Baldassano</name><affiliation wicri:level="2"><nlm:aff id="A13">The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Barclay, Murray" sort="Barclay, Murray" uniqKey="Barclay M" first="Murray" last="Barclay">Murray Barclay</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Bayless, Theodore M" sort="Bayless, Theodore M" uniqKey="Bayless T" first="Theodore M." last="Bayless">Theodore M. Bayless</name><affiliation wicri:level="2"><nlm:aff id="A15">Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brand, Stephan" sort="Brand, Stephan" uniqKey="Brand S" first="Stephan" last="Brand">Stephan Brand</name><affiliation wicri:level="3"><nlm:aff id="A16">University Hospital Munich, Department of Medicine II, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Munich, Department of Medicine II, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Buning, Carsten" sort="Buning, Carsten" uniqKey="Buning C" first="Carsten" last="Büning">Carsten Büning</name><affiliation wicri:level="3"><nlm:aff id="A17">Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsmedizin Berlin, Department of Gastroenterology, Charité, Campus Mitte, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Colombel, Jean Frederic" sort="Colombel, Jean Frederic" uniqKey="Colombel J" first="Jean-Frédéric" last="Colombel">Jean-Frédéric Colombel</name><affiliation wicri:level="3"><nlm:aff id="A18">Université de Lille Department of Hepato-Gastroenterology, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université de Lille Department of Hepato-Gastroenterology, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Denson, Lee A" sort="Denson, Lee A" uniqKey="Denson L" first="Lee A." last="Denson">Lee A. Denson</name><affiliation wicri:level="2"><nlm:aff id="A19">Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Children’s Hospital Medical Center, Pediatric Gastroenterology, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="De Vos, Martine" sort="De Vos, Martine" uniqKey="De Vos M" first="Martine" last="De Vos">Martine De Vos</name><affiliation wicri:level="1"><nlm:aff id="A20">Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Dubinsky, Marla" sort="Dubinsky, Marla" uniqKey="Dubinsky M" first="Marla" last="Dubinsky">Marla Dubinsky</name><affiliation wicri:level="2"><nlm:aff id="A21">Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Department of Pediatrics, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Edwards, Cathryn" sort="Edwards, Cathryn" uniqKey="Edwards C" first="Cathryn" last="Edwards">Cathryn Edwards</name><affiliation wicri:level="1"><nlm:aff id="A22">Torbay Hospital, Department of Gastroenterology, Torbay, Devon, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Torbay Hospital, Department of Gastroenterology, Torbay, Devon</wicri:regionArea><wicri:noRegion>Devon</wicri:noRegion></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Fehrmann, Rudolf S N" sort="Fehrmann, Rudolf S N" uniqKey="Fehrmann R" first="Rudolf S. N." last="Fehrmann">Rudolf S. N. Fehrmann</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Floyd, James A B" sort="Floyd, James A B" uniqKey="Floyd J" first="James A. B." last="Floyd">James A. B. Floyd</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Florin, Tim" sort="Florin, Tim" uniqKey="Florin T" first="Tim" last="Florin">Tim Florin</name><affiliation wicri:level="1"><nlm:aff id="A24">Mater Health Services, Department of Gastroenterology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Mater Health Services, Department of Gastroenterology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Franchimont, Denis" sort="Franchimont, Denis" uniqKey="Franchimont D" first="Denis" last="Franchimont">Denis Franchimont</name><affiliation wicri:level="3"><nlm:aff id="A25">Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Franke, Lude" sort="Franke, Lude" uniqKey="Franke L" first="Lude" last="Franke">Lude Franke</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Georges, Michel" sort="Georges, Michel" uniqKey="Georges M" first="Michel" last="Georges">Michel Georges</name><affiliation wicri:level="4"><nlm:aff id="A26">University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University of Liège, Department of Genetics, Faculty of Veterinary Medicine, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Glas, Jurgen" sort="Glas, Jurgen" uniqKey="Glas J" first="Jürgen" last="Glas">Jürgen Glas</name><affiliation wicri:level="3"><nlm:aff id="A16">University Hospital Munich, Department of Medicine II, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Munich, Department of Medicine II, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation wicri:level="4"><nlm:aff id="A27">University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington, Cardiovascular Health Research Unit, Department of Internal Medicine, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Guthery, Stephen L" sort="Guthery, Stephen L" uniqKey="Guthery S" first="Stephen L." last="Guthery">Stephen L. Guthery</name><affiliation wicri:level="2"><nlm:aff id="A28">University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah School of Medicine, Department of Pediatrics, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Hugot, Jean Pierre" sort="Hugot, Jean Pierre" uniqKey="Hugot J" first="Jean-Pierre" last="Hugot">Jean-Pierre Hugot</name><affiliation wicri:level="3"><nlm:aff id="A31">Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot & INSERM & Hopital Robert Debre APHP, Gastroenterology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jobin, Gilles" sort="Jobin, Gilles" uniqKey="Jobin G" first="Gilles" last="Jobin">Gilles Jobin</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A32">Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Hôpital Maisonneuve-Rosemont, Dept of Gastroenterology, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Laukens, Debby" sort="Laukens, Debby" uniqKey="Laukens D" first="Debby" last="Laukens">Debby Laukens</name><affiliation wicri:level="1"><nlm:aff id="A20">Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Department of Hepatology and Gastroenterology, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Lawrance, Ian" sort="Lawrance, Ian" uniqKey="Lawrance I" first="Ian" last="Lawrance">Ian Lawrance</name><affiliation wicri:level="1"><nlm:aff id="A33">The University of Western Australia, School of Medicine and Pharmacology, Fremantle, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Western Australia, School of Medicine and Pharmacology, Fremantle</wicri:regionArea><wicri:noRegion>Fremantle</wicri:noRegion></affiliation></author><author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lémann">Marc Lémann</name><affiliation wicri:level="3"><nlm:aff id="A34">Université Paris Diderot, GETAID group, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, GETAID group, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Levine, Arie" sort="Levine, Arie" uniqKey="Levine A" first="Arie" last="Levine">Arie Levine</name><affiliation wicri:level="1"><nlm:aff id="A35">Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Tel Aviv University, Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Libioulle, Cecile" sort="Libioulle, Cecile" uniqKey="Libioulle C" first="Cecile" last="Libioulle">Cecile Libioulle</name><affiliation wicri:level="1"><nlm:aff id="A36">Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Louis, Edouard" sort="Louis, Edouard" uniqKey="Louis E" first="Edouard" last="Louis">Edouard Louis</name><affiliation wicri:level="1"><nlm:aff id="A36">Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Centre Hospitalier Universitaire Université de Liège, Division of Gastroenterology, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Mcgovern, Dermot P" sort="Mcgovern, Dermot P" uniqKey="Mcgovern D" first="Dermot P." last="Mcgovern">Dermot P. Mcgovern</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Milla, Monica" sort="Milla, Monica" uniqKey="Milla M" first="Monica" last="Milla">Monica Milla</name><affiliation wicri:level="1"><nlm:aff id="A37">AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>AOU Careggi, Unit of Gastroenterology SOD2, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Morley, Katherine I" sort="Morley, Katherine I" uniqKey="Morley K" first="Katherine I." last="Morley">Katherine I. Morley</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mowat, Craig" sort="Mowat, Craig" uniqKey="Mowat C" first="Craig" last="Mowat">Craig Mowat</name><affiliation wicri:level="1"><nlm:aff id="A38">Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ninewells Hospital and Medical School, Dept of Medicine, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Aylwin" sort="Ng, Aylwin" uniqKey="Ng A" first="Aylwin" last="Ng">Aylwin Ng</name><affiliation wicri:level="2"><nlm:aff id="A39">Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A40">Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Newman, William" sort="Newman, William" uniqKey="Newman W" first="William" last="Newman">William Newman</name><affiliation wicri:level="3"><nlm:aff id="A41">University of Manchester Department of Medical Genetics, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester Department of Medical Genetics, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Ophoff, Roel A" sort="Ophoff, Roel A" uniqKey="Ophoff R" first="Roel A" last="Ophoff">Roel A. Ophoff</name><affiliation wicri:level="3"><nlm:aff id="A42">University Medical Center Utrecht, Department of Medical Genetics, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Department of Medical Genetics, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation wicri:level="1"><nlm:aff id="A43">University of Florence, Institute of Human Genetics, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Florence, Institute of Human Genetics, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Palmieri, Orazio" sort="Palmieri, Orazio" uniqKey="Palmieri O" first="Orazio" last="Palmieri">Orazio Palmieri</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Peyrin Biroulet, Laurent" sort="Peyrin Biroulet, Laurent" uniqKey="Peyrin Biroulet L" first="Laurent" last="Peyrin-Biroulet">Laurent Peyrin-Biroulet</name><affiliation wicri:level="3"><nlm:aff id="A44">University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Nancy, Department of Hepato-Gastroenterology, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Panes, Julian" sort="Panes, Julian" uniqKey="Panes J" first="Julián" last="Panés">Julián Panés</name><affiliation wicri:level="3"><nlm:aff id="A45">Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Phillips, Anne" sort="Phillips, Anne" uniqKey="Phillips A" first="Anne" last="Phillips">Anne Phillips</name><affiliation wicri:level="1"><nlm:aff id="A38">Ninewells Hospital and Medical School, Dept of Medicine, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ninewells Hospital and Medical School, Dept of Medicine, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Prescott, Natalie J" sort="Prescott, Natalie J" uniqKey="Prescott N" first="Natalie J." last="Prescott">Natalie J. Prescott</name><affiliation wicri:level="3"><nlm:aff id="A46">King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Proctor, Deborah D" sort="Proctor, Deborah D" uniqKey="Proctor D" first="Deborah D." last="Proctor">Deborah D. Proctor</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Roberts, Rebecca" sort="Roberts, Rebecca" uniqKey="Roberts R" first="Rebecca" last="Roberts">Rebecca Roberts</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Richard" sort="Russell, Richard" uniqKey="Russell R" first="Richard" last="Russell">Richard Russell</name><affiliation wicri:level="1"><nlm:aff id="A48">Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Rutgeerts, Paul" sort="Rutgeerts, Paul" uniqKey="Rutgeerts P" first="Paul" last="Rutgeerts">Paul Rutgeerts</name><affiliation wicri:level="1"><nlm:aff id="A49">University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sanderson, Jeremy" sort="Sanderson, Jeremy" uniqKey="Sanderson J" first="Jeremy" last="Sanderson">Jeremy Sanderson</name><affiliation wicri:level="3"><nlm:aff id="A50">Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy’s & St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Dept Gastroenterology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sans, Miquel" sort="Sans, Miquel" uniqKey="Sans M" first="Miquel" last="Sans">Miquel Sans</name><affiliation wicri:level="3"><nlm:aff id="A51">Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, Department of Gastroenterology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Schumm, Philip" sort="Schumm, Philip" uniqKey="Schumm P" first="Philip" last="Schumm">Philip Schumm</name><affiliation wicri:level="2"><nlm:aff id="A52">University of Chicago, Department of Health Studies, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Department of Health Studies, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Seibold, Frank" sort="Seibold, Frank" uniqKey="Seibold F" first="Frank" last="Seibold">Frank Seibold</name><affiliation wicri:level="4"><nlm:aff id="A53">University of Bern, Division of Gastroenterology, Inselspital, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Bern, Division of Gastroenterology, Inselspital, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Sharma, Yashoda" sort="Sharma, Yashoda" uniqKey="Sharma Y" first="Yashoda" last="Sharma">Yashoda Sharma</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Simms, Lisa" sort="Simms, Lisa" uniqKey="Simms L" first="Lisa" last="Simms">Lisa Simms</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Seielstad, Mark" sort="Seielstad, Mark" uniqKey="Seielstad M" first="Mark" last="Seielstad">Mark Seielstad</name><affiliation wicri:level="1"><nlm:aff id="A54">Genome Institute of Singapore, Human Genetics, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore, Human Genetics</wicri:regionArea><wicri:noRegion>Human Genetics</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A55">Institute for Human Genetics, University of California San Fransisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Human Genetics, University of California San Fransisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Steinhart, A Hillary" sort="Steinhart, A Hillary" uniqKey="Steinhart A" first="A. Hillary" last="Steinhart">A. Hillary Steinhart</name><affiliation wicri:level="4"><nlm:aff id="A56">University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Targan, Stephan R" sort="Targan, Stephan R" uniqKey="Targan S" first="Stephan R." last="Targan">Stephan R. Targan</name><affiliation wicri:level="2"><nlm:aff id="A7">Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Van Den Berg, Leonard H" sort="Van Den Berg, Leonard H" uniqKey="Van Den Berg L" first="Leonard H." last="Van Den Berg">Leonard H. Van Den Berg</name><affiliation wicri:level="3"><nlm:aff id="A57">Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Neurology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Vatn, Morten" sort="Vatn, Morten" uniqKey="Vatn M" first="Morten" last="Vatn">Morten Vatn</name><affiliation wicri:level="3"><nlm:aff id="A58">Rikshospitalet University Hospital, Medical Department, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Rikshospitalet University Hospital, Medical Department, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Verspaget, Hein" sort="Verspaget, Hein" uniqKey="Verspaget H" first="Hein" last="Verspaget">Hein Verspaget</name><affiliation wicri:level="3"><nlm:aff id="A59">Leiden University Medical Center, Experimental Gastroenterology, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Leiden University Medical Center, Experimental Gastroenterology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Walters, Thomas" sort="Walters, Thomas" uniqKey="Walters T" first="Thomas" last="Walters">Thomas Walters</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Wilson, David C" sort="Wilson, David C" uniqKey="Wilson D" first="David C." last="Wilson">David C. Wilson</name><affiliation wicri:level="1"><nlm:aff id="A48">Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A61">Child Life and Health, University of Edinburgh, Scotland</nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Écosse</region></placeName><wicri:cityArea>Child Life and Health, University of Edinburgh</wicri:cityArea></affiliation></author><author><name sortKey="Westra, Harm Jan" sort="Westra, Harm Jan" uniqKey="Westra H" first="Harm-Jan" last="Westra">Harm-Jan Westra</name><affiliation wicri:level="3"><nlm:aff id="A23">University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Genetics, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Xavier, Ramnik J" sort="Xavier, Ramnik J" uniqKey="Xavier R" first="Ramnik J." last="Xavier">Ramnik J. Xavier</name><affiliation wicri:level="2"><nlm:aff id="A39">Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Gastroenterology Unit Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A40">Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhao, Zhen Z" sort="Zhao, Zhen Z" uniqKey="Zhao Z" first="Zhen Z." last="Zhao">Zhen Z. Zhao</name><affiliation wicri:level="1"><nlm:aff id="A30">Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Ponsioen, Cyriel Y" sort="Ponsioen, Cyriel Y" uniqKey="Ponsioen C" first="Cyriel Y." last="Ponsioen">Cyriel Y. Ponsioen</name><affiliation wicri:level="3"><nlm:aff id="A62">Academic Medical Center, Department of Gastroenterology, Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Academic Medical Center, Department of Gastroenterology, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Andersen, Vibeke" sort="Andersen, Vibeke" uniqKey="Andersen V" first="Vibeke" last="Andersen">Vibeke Andersen</name><affiliation wicri:level="1"><nlm:aff id="A63">Viborg Regional Hospital, Medical Department, Viborg, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Viborg Regional Hospital, Medical Department, Viborg</wicri:regionArea><wicri:noRegion>Viborg</wicri:noRegion></affiliation></author><author><name sortKey="Torkvist, Leif" sort="Torkvist, Leif" uniqKey="Torkvist L" first="Leif" last="Torkvist">Leif Torkvist</name><affiliation wicri:level="3"><nlm:aff id="A64">Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Department of Clinical Science Intervention and Technology, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gazouli, Maria" sort="Gazouli, Maria" uniqKey="Gazouli M" first="Maria" last="Gazouli">Maria Gazouli</name><affiliation wicri:level="3"><nlm:aff id="A65">University of Athens, Department of Biology, School of Medicine, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Athens, Department of Biology, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Anagnou, Nicholas P" sort="Anagnou, Nicholas P" uniqKey="Anagnou N" first="Nicholas P." last="Anagnou">Nicholas P. Anagnou</name><affiliation wicri:level="3"><nlm:aff id="A65">University of Athens, Department of Biology, School of Medicine, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Athens, Department of Biology, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Karlsen, Tom H" sort="Karlsen, Tom H" uniqKey="Karlsen T" first="Tom H." last="Karlsen">Tom H. Karlsen</name><affiliation wicri:level="3"><nlm:aff id="A58">Rikshospitalet University Hospital, Medical Department, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Rikshospitalet University Hospital, Medical Department, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Kupcinskas, Limas" sort="Kupcinskas, Limas" uniqKey="Kupcinskas L" first="Limas" last="Kupcinskas">Limas Kupcinskas</name><affiliation wicri:level="1"><nlm:aff id="A66">Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Kaunas University of medicine, Department of Gastroenterology, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Sventoraityte, Jurgita" sort="Sventoraityte, Jurgita" uniqKey="Sventoraityte J" first="Jurgita" last="Sventoraityte">Jurgita Sventoraityte</name><affiliation wicri:level="1"><nlm:aff id="A66">Kaunas University of medicine, Department of Gastroenterology, Kaunas, Lithuania</nlm:aff><country xml:lang="fr">Lituanie</country><wicri:regionArea>Kaunas University of medicine, Department of Gastroenterology, Kaunas</wicri:regionArea><wicri:noRegion>Kaunas</wicri:noRegion></affiliation></author><author><name sortKey="Mansfield, John C" sort="Mansfield, John C" uniqKey="Mansfield J" first="John C." last="Mansfield">John C. Mansfield</name><affiliation wicri:level="1"><nlm:aff id="A67">Newcastle University, Institute of Human Genetics, Newcastle upon Tyne, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Newcastle University, Institute of Human Genetics, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Kugathasan, Subra" sort="Kugathasan, Subra" uniqKey="Kugathasan S" first="Subra" last="Kugathasan">Subra Kugathasan</name><affiliation wicri:level="2"><nlm:aff id="A68">Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory School of Medicine, Department of Genetics and Department of Pediatrics, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Silverberg, Mark S" sort="Silverberg, Mark S" uniqKey="Silverberg M" first="Mark S." last="Silverberg">Mark S. Silverberg</name><affiliation wicri:level="4"><nlm:aff id="A56">University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Mount Sinai Hospital Inflammatory Bowel Disease Centre, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Halfvarson, Jonas" sort="Halfvarson, Jonas" uniqKey="Halfvarson J" first="Jonas" last="Halfvarson">Jonas Halfvarson</name><affiliation wicri:level="1"><nlm:aff id="A69">Örebro University Hospital, Department of Medicine, Örebro, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Örebro University Hospital, Department of Medicine, Örebro</wicri:regionArea><wicri:noRegion>Örebro</wicri:noRegion></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:aff id="A29">Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Medical Center, Medical Genetics Institute, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mathew, Christopher G" sort="Mathew, Christopher G" uniqKey="Mathew C" first="Christopher G." last="Mathew">Christopher G. Mathew</name><affiliation wicri:level="3"><nlm:aff id="A46">King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King’s College London School of Medicine, Guy’s Hospital, Department of Medical and Molecular Genetics, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Griffiths, Anne M" sort="Griffiths, Anne M" uniqKey="Griffiths A" first="Anne M." last="Griffiths">Anne M. Griffiths</name><affiliation wicri:level="4"><nlm:aff id="A60">The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gearry, Richard" sort="Gearry, Richard" uniqKey="Gearry R" first="Richard" last="Gearry">Richard Gearry</name><affiliation wicri:level="1"><nlm:aff id="A14">University of Otago, Department of Medicine, Christchurch, New Zealand</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Department of Medicine, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Tariq" sort="Ahmad, Tariq" uniqKey="Ahmad T" first="Tariq" last="Ahmad">Tariq Ahmad</name><affiliation wicri:level="1"><nlm:aff id="A70">Peninsula College of Medicine and Dentistry, Barrack Road, Exeter, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula College of Medicine and Dentistry, Barrack Road, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Brant, Steven R" sort="Brant, Steven R" uniqKey="Brant S" first="Steven R." last="Brant">Steven R. Brant</name><affiliation wicri:level="2"><nlm:aff id="A15">Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University School of Medicine, Meyeroff Inflammatory Bowel Disease Center, Dept. of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chamaillard, Mathias" sort="Chamaillard, Mathias" uniqKey="Chamaillard M" first="Mathias" last="Chamaillard">Mathias Chamaillard</name><affiliation wicri:level="3"><nlm:aff id="A71">Inserm, U1019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1019, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Satsangi, Jack" sort="Satsangi, Jack" uniqKey="Satsangi J" first="Jack" last="Satsangi">Jack Satsangi</name><affiliation wicri:level="4"><nlm:aff id="A4">University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Edinburgh, Western General Hospital, Gastrointestinal Unit, Molecular Medicine Centre, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Cho, Judy H" sort="Cho, Judy H" uniqKey="Cho J" first="Judy H." last="Cho">Judy H. Cho</name><affiliation wicri:level="2"><nlm:aff id="A47">Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale University, Section of Digestive Diseases, Department of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation><nlm:aff id="A72">Yale University, Department of Genetics, Yale School of Medicine, New Haven CT</nlm:aff><wicri:noCountry code="subfield">New Haven CT</wicri:noCountry></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation wicri:level="3"><nlm:aff id="A5">Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A73">Department for General Internal Medicine, Christian-Albrechts-University, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for General Internal Medicine, Christian-Albrechts-University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J." last="Daly">Mark J. Daly</name><affiliation wicri:level="2"><nlm:aff id="A74">Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Harvard Medical School, Center for Human Genetic Research, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Barrett, Jeffrey C" sort="Barrett, Jeffrey C" uniqKey="Barrett J" first="Jeffrey C." last="Barrett">Jeffrey C. Barrett</name><affiliation wicri:level="1"><nlm:aff id="A1">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Parkes, Miles" sort="Parkes, Miles" uniqKey="Parkes M" first="Miles" last="Parkes">Miles Parkes</name><affiliation wicri:level="4"><nlm:aff id="A8">Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Addenbrooke’s Hospital, University of Cambridge, Gastroenterology Research Unit, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Annese, Vito" sort="Annese, Vito" uniqKey="Annese V" first="Vito" last="Annese">Vito Annese</name><affiliation wicri:level="1"><nlm:aff id="A10">IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS-CSS Hospital, Unit of Gastroenterology, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A37">AOU Careggi, Unit of Gastroenterology SOD2, Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>AOU Careggi, Unit of Gastroenterology SOD2, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:aff id="A13">The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Children’s Hospital of Philadelphia, Department of Pediatrics, Center for Pediatric Inflammatory Bowel Disease, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A75">Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Radford Smith, Graham" sort="Radford Smith, Graham" uniqKey="Radford Smith G" first="Graham" last="Radford-Smith">Graham Radford-Smith</name><affiliation wicri:level="1"><nlm:aff id="A76">Queensland Institute of Medical Research, IBD Research Group, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, IBD Research Group, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Duerr, Richard H" sort="Duerr, Richard H" uniqKey="Duerr R" first="Richard H." last="Duerr">Richard H. Duerr</name><affiliation wicri:level="2"><nlm:aff id="A11">University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A77">University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Graduate School of Public Health, 130 Desoto Street, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Vermeire, Severine" sort="Vermeire, Severine" uniqKey="Vermeire S" first="Séverine" last="Vermeire">Séverine Vermeire</name><affiliation wicri:level="1"><nlm:aff id="A49">University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Division of Gastroenterology, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Weersma, Rinse K" sort="Weersma, Rinse K" uniqKey="Weersma R" first="Rinse K." last="Weersma">Rinse K. Weersma</name><affiliation wicri:level="3"><nlm:aff id="A78">University Medical Center Groningen, Department of Gastroenterology, Groningen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, Department of Gastroenterology, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D." last="Rioux">John D. Rioux</name><affiliation wicri:level="1"><nlm:aff id="A2">Université de Montréal, Medicine, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Montréal, Medicine, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3">Montreal Heart Institute, Research Center, Montréal, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute, Research Center, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Genome-wide association studies (GWAS) and candidate gene studies in ulcerative colitis (UC) have identified 18 susceptibility loci. We conducted a meta-analysis of 6 UC GWAS, comprising 6,687 cases and 19,718 controls, and followed-up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P<5×10<sup>-8</sup>), increasing the number of UC associated loci to 47. After annotating associated regions using GRAIL, eQTL data and correlations with non-synonymous SNPs, we identified many candidate genes providing potentially important insights into disease pathogenesis, including <italic>IL1R2, IL8RA/B, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12</italic> and <italic>LSP1</italic>. The total number of confirmed inflammatory bowel disease (IBD) risk loci is now 99, including a minimum of 28 shared association signals between Crohn’s disease (CD) and UC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Xavier, Rj" uniqKey="Xavier R">RJ Xavier</name></author><author><name sortKey="Podolsky, Dk" uniqKey="Podolsky D">DK Podolsky</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Festen, Ea" uniqKey="Festen E">EA Festen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franke, A" uniqKey="Franke A">A Franke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgovern, Dp" uniqKey="Mcgovern D">DP McGovern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franke, A" uniqKey="Franke A">A 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uniqKey="Kallies A">A Kallies</name></author><author><name sortKey="Xin, A" uniqKey="Xin A">A Xin</name></author><author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name></author><author><name sortKey="Nutt, Sl" uniqKey="Nutt S">SL Nutt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grenningloh, R" uniqKey="Grenningloh R">R Grenningloh</name></author><author><name sortKey="Kang, By" uniqKey="Kang B">BY Kang</name></author><author><name sortKey="Ho, Ic" uniqKey="Ho I">IC Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moisan, J" uniqKey="Moisan J">J Moisan</name></author><author><name sortKey="Grenningloh, R" uniqKey="Grenningloh R">R Grenningloh</name></author><author><name sortKey="Bettelli, E" uniqKey="Bettelli E">E Bettelli</name></author><author><name sortKey="Oukka, M" uniqKey="Oukka M">M Oukka</name></author><author><name sortKey="Ho, Ic" uniqKey="Ho I">IC 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D">DP Jewell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Ej" uniqKey="Williams E">EJ Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noble, Cl" uniqKey="Noble C">CL Noble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schluns, Ks" uniqKey="Schluns K">KS Schluns</name></author><author><name sortKey="Kieper, Wc" uniqKey="Kieper W">WC Kieper</name></author><author><name sortKey="Jameson, Sc" uniqKey="Jameson S">SC Jameson</name></author><author><name sortKey="Lefrancois, L" uniqKey="Lefrancois L">L Lefrancois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamazaki, M" uniqKey="Yamazaki M">M Yamazaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gregory, Sg" uniqKey="Gregory S">SG Gregory</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fumagalli, M" uniqKey="Fumagalli M">M Fumagalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandey, Ak" uniqKey="Pandey A">AK Pandey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Israël</li><li>Italie</li><li>Lituanie</li><li>Norvège</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Singapour</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Attique (région)</li><li>Bavière</li><li>Berlin</li><li>Californie</li><li>Canton de Berne</li><li>Catalogne</li><li>Connecticut</li><li>District de Haute-Bavière</li><li>Grand Est</li><li>Grand Londres</li><li>Grand Manchester</li><li>Groningue (province)</li><li>Géorgie (États-Unis)</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Illinois</li><li>Lorraine (région)</li><li>Maryland</li><li>Massachusetts</li><li>Nord-Pas-de-Calais</li><li>Ohio</li><li>Ontario</li><li>Pennsylvanie</li><li>Province de Liège</li><li>Région de Bruxelles-Capitale</li><li>Région wallonne</li><li>Schleswig-Holstein</li><li>Svealand</li><li>Utah</li><li>Utrecht (province)</li><li>Washington (État)</li><li>Écosse</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Amsterdam</li><li>Athènes</li><li>Barcelone</li><li>Berlin</li><li>Berne</li><li>Bruxelles</li><li>Cambridge</li><li>Groningue</li><li>Kiel</li><li>Leyde</li><li>Lille</li><li>Liège</li><li>Londres</li><li>Manchester</li><li>Munich</li><li>Nancy</li><li>Oslo</li><li>Paris</li><li>Seattle</li><li>Stockholm</li><li>Toronto</li><li>Utrecht</li><li>Vandœuvre-lès-Nancy</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Berne</li><li>Université de Cambridge</li><li>Université de Liège</li><li>Université de Toronto</li><li>Université de Washington</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Anderson, Carl A" sort="Anderson, Carl A" uniqKey="Anderson C" first="Carl A." last="Anderson">Carl A. Anderson</name></noRegion><name sortKey="Ahmad, Tariq" sort="Ahmad, Tariq" uniqKey="Ahmad T" first="Tariq" last="Ahmad">Tariq Ahmad</name><name sortKey="Barrett, Jeffrey C" sort="Barrett, Jeffrey C" uniqKey="Barrett J" first="Jeffrey C." last="Barrett">Jeffrey C. Barrett</name><name sortKey="Bumpstead, Suzannah" sort="Bumpstead, Suzannah" uniqKey="Bumpstead S" first="Suzannah" last="Bumpstead">Suzannah Bumpstead</name><name sortKey="Edwards, Cathryn" sort="Edwards, Cathryn" uniqKey="Edwards C" first="Cathryn" last="Edwards">Cathryn Edwards</name><name sortKey="Floyd, James A B" sort="Floyd, James A B" uniqKey="Floyd J" first="James A. B." last="Floyd">James A. B. Floyd</name><name sortKey="Lee, James C" sort="Lee, James C" uniqKey="Lee J" first="James C." last="Lee">James C. Lee</name><name sortKey="Lees, Charlie W" sort="Lees, Charlie W" uniqKey="Lees C" first="Charlie W." last="Lees">Charlie W. Lees</name><name sortKey="Mansfield, John C" sort="Mansfield, John C" uniqKey="Mansfield J" first="John C." last="Mansfield">John C. Mansfield</name><name sortKey="Mathew, Christopher G" sort="Mathew, Christopher G" uniqKey="Mathew C" first="Christopher G." last="Mathew">Christopher G. Mathew</name><name sortKey="Morley, Katherine I" sort="Morley, Katherine I" uniqKey="Morley K" first="Katherine I." last="Morley">Katherine I. Morley</name><name sortKey="Mowat, Craig" sort="Mowat, Craig" uniqKey="Mowat C" first="Craig" last="Mowat">Craig Mowat</name><name sortKey="Newman, William" sort="Newman, William" uniqKey="Newman W" first="William" last="Newman">William Newman</name><name sortKey="Parkes, Miles" sort="Parkes, Miles" uniqKey="Parkes M" first="Miles" last="Parkes">Miles Parkes</name><name sortKey="Phillips, Anne" sort="Phillips, Anne" uniqKey="Phillips A" first="Anne" last="Phillips">Anne Phillips</name><name sortKey="Prescott, Natalie J" sort="Prescott, Natalie J" uniqKey="Prescott N" first="Natalie J." last="Prescott">Natalie J. Prescott</name><name sortKey="Russell, Richard" sort="Russell, Richard" uniqKey="Russell R" first="Richard" last="Russell">Richard Russell</name><name sortKey="Sanderson, Jeremy" sort="Sanderson, Jeremy" uniqKey="Sanderson J" first="Jeremy" last="Sanderson">Jeremy Sanderson</name><name sortKey="Satsangi, Jack" sort="Satsangi, Jack" uniqKey="Satsangi J" first="Jack" last="Satsangi">Jack Satsangi</name><name sortKey="Wilson, David C" sort="Wilson, David C" uniqKey="Wilson D" first="David C." last="Wilson">David C. Wilson</name><name sortKey="Wilson, David C" sort="Wilson, David C" uniqKey="Wilson D" first="David C." last="Wilson">David C. Wilson</name></country><country name="Canada"><noRegion><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name></noRegion><name sortKey="Boucher, Gabrielle" sort="Boucher, Gabrielle" uniqKey="Boucher G" first="Gabrielle" last="Boucher">Gabrielle Boucher</name><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><name sortKey="Goyette, Philippe" sort="Goyette, Philippe" uniqKey="Goyette P" first="Philippe" last="Goyette">Philippe Goyette</name><name sortKey="Griffiths, Anne M" sort="Griffiths, Anne M" uniqKey="Griffiths A" first="Anne M." last="Griffiths">Anne M. Griffiths</name><name sortKey="Jobin, Gilles" sort="Jobin, Gilles" uniqKey="Jobin G" first="Gilles" last="Jobin">Gilles Jobin</name><name sortKey="Jobin, Gilles" sort="Jobin, Gilles" uniqKey="Jobin G" first="Gilles" last="Jobin">Gilles Jobin</name><name sortKey="Lagace, Caroline" sort="Lagace, Caroline" uniqKey="Lagace C" first="Caroline" last="Lagacé">Caroline Lagacé</name><name sortKey="Lagace, Caroline" sort="Lagace, Caroline" uniqKey="Lagace C" first="Caroline" last="Lagacé">Caroline Lagacé</name><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D." last="Rioux">John D. Rioux</name><name sortKey="Rioux, John D" sort="Rioux, John D" uniqKey="Rioux J" first="John D." last="Rioux">John D. Rioux</name><name sortKey="Silverberg, Mark S" sort="Silverberg, Mark S" uniqKey="Silverberg M" first="Mark S." last="Silverberg">Mark S. Silverberg</name><name sortKey="Steinhart, A Hillary" sort="Steinhart, A Hillary" uniqKey="Steinhart A" first="A. Hillary" last="Steinhart">A. Hillary Steinhart</name><name sortKey="Walters, Thomas" sort="Walters, Thomas" uniqKey="Walters T" first="Thomas" last="Walters">Thomas Walters</name></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name></region><name sortKey="Brand, Stephan" sort="Brand, Stephan" uniqKey="Brand S" first="Stephan" last="Brand">Stephan Brand</name><name sortKey="Buning, Carsten" sort="Buning, Carsten" uniqKey="Buning C" first="Carsten" last="Büning">Carsten Büning</name><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><name sortKey="Glas, Jurgen" sort="Glas, Jurgen" uniqKey="Glas J" first="Jürgen" last="Glas">Jürgen Glas</name><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name></country><country name="Suède"><region name="Svealand"><name sortKey="D Mato, Mauro" sort="D Mato, Mauro" uniqKey="D Mato M" first="Mauro" last="D Mato">Mauro D Mato</name></region><name sortKey="Halfvarson, Jonas" sort="Halfvarson, Jonas" uniqKey="Halfvarson J" first="Jonas" last="Halfvarson">Jonas Halfvarson</name><name sortKey="Torkvist, Leif" sort="Torkvist, Leif" uniqKey="Torkvist L" first="Leif" last="Torkvist">Leif Torkvist</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D." last="Taylor">Kent D. 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Karlsen</name></country><country name="Danemark"><noRegion><name sortKey="Andersen, Vibeke" sort="Andersen, Vibeke" uniqKey="Andersen V" first="Vibeke" last="Andersen">Vibeke Andersen</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Gazouli, Maria" sort="Gazouli, Maria" uniqKey="Gazouli M" first="Maria" last="Gazouli">Maria Gazouli</name></region><name sortKey="Anagnou, Nicholas P" sort="Anagnou, Nicholas P" uniqKey="Anagnou N" first="Nicholas P." last="Anagnou">Nicholas P. Anagnou</name></country><country name="Lituanie"><noRegion><name sortKey="Kupcinskas, Limas" sort="Kupcinskas, Limas" uniqKey="Kupcinskas L" first="Limas" last="Kupcinskas">Limas Kupcinskas</name></noRegion><name sortKey="Sventoraityte, Jurgita" sort="Sventoraityte, Jurgita" uniqKey="Sventoraityte J" first="Jurgita" last="Sventoraityte">Jurgita Sventoraityte</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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